Category: News
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eNIOS was awarded the 1st prize of Pfizer’s accelerator Start4Health
eNIOS was awarded the 1st prize of Start4Health, an accelerator organized by Pfizer’s Center of Digital Innovation. Start4Health focused on Digital Health and targeted startup companies that develop solutions that can tackle challenges of the health industry, improve the digital experience of patients and promote wellness through technology. eNIOS worked…
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Integration of Raman spectra with transcriptome data in glioblastoma multiforme defines tumour subtypes and predicts patient outcome
Glioblastoma Multiforme is the most aggressive form of primary brain tumors. Raman spectroscopy is an imaging technique that has been applied to assess molecular compositions of living cells to characterize cell types and states. However, owing to the diverse molecular species in cells and challenges of assigning peaks to specific…
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Epigenetics in Breast Cancer Therapy-New Strategies and Future Nanomedicine Perspectives
e-NIOS is a partner of the international INNOCENT project, with the aim to develop an innovative multifunctional nano-pharmaceutical to overcome the low efficacy and frequent relapses in breast cancer treatment. The use of nano-based delivery systems, together with the benefits of a new generation of epi-drugs and the emergence of…
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BioInfoMiner elucidates the role of the early secretory pathway in SARS-CoV-2 infection
https://doi.org/10.1083/jcb.202006005 Here, we analyze and discuss the contribution of the molecular machines operating in the early secretory pathway in the biogenesis of SARS-CoV-2 and their relevance for potential antiviral targeting. The fact that these molecular machines are conserved throughout evolution, together with the redundancy and tissue specificity of their components,…
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RA-map: a state-of-the-art interactive knowledge base for rheumatoid arthritis
RA-map is a fully annotated, expert validated, state-of-the-art knowledge base for RA in the form of a molecular map. BioInfoMiner was used for topological, functional and pharmacogenomic analysis. The publication is accessible at: Vidisha Singh, George D Kalliolias, Marek Ostaszewski, Maëva Veyssiere, Eleftherios Pilalis, Piotr Gawron, Alexander Mazein, Eric Bonnet,…
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New publication on bioinformatic analysis of phage display experiments
In this publication, we introduce PepSimili, an integrated workflow tool, which performs mapping of massive peptide repertoires on whole proteomes and delivers a streamlined, systems-level biological interpretation. https://www.frontiersin.org/articles/10.3389/fphys.2019.01160/full
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New e-NIOS’ study links proteostasis with inflammation and suggests a therapeutic approach for Crohn’s disease (EMBO Molecular Medicine)
Find our new paper here. The molecular mechanisms underlying inflammatory bowel diseases remain currently not completely understood, and therapeutic options are scarce. Herein, we have identified that a normally endoplasmic reticulum resident protein, AGR2, exhibits tightly regulated secretion mechanisms that are perturbed in Crohn’s disease. We demonstrate that the extracellular…
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Join us at Bio-IT World 2019 Boston
e-NIOS is excited to participate in Bio-IT World, 16-18 April 2019, Boston. Join us at Seven Bridges’ booth #332 in the Exhibit Hall, for a demonstration of signature-based interpretation on the Seven Bridges Platform with BioInfoMiner!
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Collaborative publication with DKFZ, ACCC and NHRF on Radiogenomics and Colorectal Cancer towards Precision Medicine
This is a new e-NIOS’ collaborative work on composite biomarker signatures, combining genomics with positron emission tomography (PET) measurements. Online paper (open access) The Athens Comprehensive Cancer Center (ACCC) was founded in 2017, in partnership with the German Cancer Research Center (DKFZ) (Heidelberg, Germany) and aims to position itself as…