New publication involving BioInfoMiner analysis suggests induction of IRE1α-dependent Anticancer Immunosurveillance by low-protein diet (Cell Metabolism)
A new paper involving the participation of e-NIOS and a BioInfoMiner-derived biomarker signature was published in the high impact journal Cell Metabolism.
Dietary restriction was shown to impact on tumor growth with very variable effects depending on the cancer type. However, how dietary restriction limits cancer progression remains largely unknown. In this publication, we demonstrate that feeding mice a low-protein isocaloric diet but not a low-carbohydrate diet reduced tumor growth in three independent mouse cancer models. Surprisingly, this effect relies on anticancer immunosurveillance. Mechanistically, we established that a low protein diet induces the unfolded protein response (UPR) in tumor cells through the activation of IRE1α and RIG1 signaling, thereby resulting in cytokine production and mounting an efficient anticancer immune response.